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The crystallographic structure of the bovine erythrocyte GPx-1 identified Gln and Trp amino acids that, with Sec, form a catalytic triad that is crucial for enzyme–substrate interactions (107)

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Dox at different doses and treatment regimens has been for years a valuable tool for the experimental reproduction of DCM/HF, which has contributed to elucidate molecular pathogenic determinants of its underlying cardiotoxicity (Hullin et al., 2018

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